AN RNA APTAMER PROVIDES A NOVEL APPROACH FOR THE INDUCTION OF APOPTOSIS BY TARGETING THE HPV16 E7 ONCOPROTEIN.

An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein.

BackgroundHuman papillomavirus 16 (HPV16) is a high-risk DNA tumour virus, which is a major causative agent of cervical cancer.Cellular transformation is associated with deregulated expression of the E6 and E7 oncogenes.E7 has been shown to bind a number of cellular proteins, including the cell cycle control protein pRb.In this study, RNA aptamers

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Secondary metabolites from the roots of Astragalus maximus

Background and objectives: Astragalus is one of the most abundant genera of flowering plants in Iran.There are a few reports on phytochemical investigation of this valuable genus.Saponins, flavonoids and polysaccharides have been reported as the most important metabolites in Astragalus species.In the present research, we aimed to identify the forem

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