An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein.
BackgroundHuman papillomavirus 16 (HPV16) is a high-risk DNA tumour virus, which is a major causative agent of cervical cancer.Cellular transformation is associated with deregulated expression of the E6 and E7 oncogenes.E7 has been shown to bind a number of cellular proteins, including the cell cycle control protein pRb.In this study, RNA aptamers